【摘 要】
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Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide, affecting 24％ of the population, and is impacting on globa
【机 构】
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UCL Institute for Liver and Digestive Health,Royal Free Hospital and UCL,London,UK“,”Division of Gas
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Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide, affecting 24％ of the population, and is impacting on global public health care with a considerable financial burden (1). NAFLD encompasses a wide disease spectrum ranging from simple steatosis to non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis. Patients with simple steatosis typically do not develop liver-related complications, whereas patients with NASH are at increased risk of hepatic and extra-hepatic mortality. Furthermore, NAFLD is associated with an increased risk of type 2 diabetes, cardiovascular disease and cancer (2). In addition, NASH is the second leading cause of cirrhosis in adult patients on the liver transplant waiting list in the United States (3,4).
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