论文部分内容阅读
目的:探讨阿托伐他汀与辛伐他汀治疗冠心病心绞痛的临床效果以及安全性。方法:根据不同的治疗药物,将2014年5月至2016年5月惠州市惠城区小金口人民医院收治的107例冠心病心绞痛患者分为阿托伐他汀组(n=54)与辛伐他汀组(n=53),比较治疗前、后两组患者心绞痛的疼痛程度、持续时间、发作次数以及硝酸甘油用量、血清血脂变化情况。随访半年,比较两组患者的心血管事件发生率。结果:与本组治疗前比较,治疗后两组患者心绞痛发作时的疼痛程度明显减轻、持续时间明显缩短、硝酸甘油用量及发作次数明显减少,差异具有统计学意义(P<0.05),但上述指标组间比较,差异无统计学意义(P>0.05);治疗3个月后组内比较低密度脂蛋白-胆固醇(LDL-C)、三酰甘油(TG)、总胆固醇(TC)比治疗前下降明显、高密度脂蛋白-胆固醇(HDL-C)比治疗前明显上升,上述血清血脂水平组间比较,差异无统计学意义(P>0.05);两组患者心血管事件发生率比较,差异无统计学意义(P>0.05)。结论:阿托伐他汀与辛伐他汀两种药物在冠心病心绞痛的临床治疗中均有明显效果,能够有效调节患者血脂水平。
Objective: To investigate the clinical effect and safety of atorvastatin and simvastatin in the treatment of angina pectoris. Methods: A total of 107 patients with angina pectoris who were admitted to Xiaojinkou People’s Hospital, Huicheng District, Huizhou from May 2014 to May 2016 were divided into atorvastatin group (n = 54) and simvastatin (N = 53). The severity of angina pectoris, duration, number of seizures, nitroglycerin consumption and serum lipids were compared between the two groups before and after treatment. Follow-up six months, comparing the two groups of patients with cardiovascular events. Results: Compared with the group before treatment, the pain degree of angina pectoris patients in the two groups were significantly reduced, the duration was significantly shortened, the dosage of nitroglycerin and the number of seizures were significantly decreased, the difference was statistically significant (P <0.05) There was no significant difference between the two groups (P> 0.05). After 3 months of treatment, the levels of LDL-C, triglyceride (TG) and total cholesterol (TC) (P <0.05). The incidence of cardiovascular events in the two groups was significantly higher than that before treatment (P <0.05). Compared with before treatment, HDL-C significantly increased before treatment. There was no significant difference between the two groups The difference was not statistically significant (P> 0.05). Conclusion: Both atorvastatin and simvastatin have significant effects in the clinical treatment of angina pectoris, which can effectively regulate the level of blood lipid in patients.