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本研究应用多项排卵监测指标对３３例月经周期正常的育龄妇女，于卵泡中期、排卵日和黄体中期测定血清泌乳素（ＰＲＬ）及微量元素的含量，以探讨月经周期中ＰＲＬ的变化规律及其与微量元素的相互关系。结果表明：血清ＰＲＬ水平在黄体中期最高，明显高于卵泡中期（Ｐ＜０．０５），在周期中呈递升趋势；卵泡中期血清ＰＲＬ与镍含量呈正相关（ｒ＝０．５６６８，Ｐ＜０．００５），与铜负相关（ｒ＝－０．５３８２，Ｐ＜０．０１）；排卵日ＰＲＬ与铁呈显著正相关（ｒ＝０．６５２６，Ｐ＜０．００１）；黄体中期ＰＲＬ与镍呈负相关（ｒ＝－０．４３６４，Ｐ＜０．０５），且与孕酮浓度呈正相关（Ｐ＜０．０１）。研究提示：血清ＰＲＬ水平存在周期性变化，可能与微量元素之间的相互作用和调节有关，黄体中期ＰＲＬ的生理性增高可促进孕酮的合成及黄体功能的维持
In this study, a number of ovulation monitoring indicators of 33 cases of normal menstrual cycle of women of childbearing age, mid-follicle, ovulation day and mid-luteal determination of serum prolactin (PRL) and trace elements in order to explore the menstrual cycle PRL changes and Its relationship with trace elements. The results showed that serum prolactin level was the highest in the mid luteal phase, significantly higher than that in the metaphase follicle (P <0.05), and was positively correlated with the nickel content in the mid follicular phase (r = 0.5668, P <0 (R = -0.5382, P <0.01). There was a significant positive correlation between PRL and iron on ovulation day (r = 0.6526, P <0.001) Nickel (r = -0.4364, P <0.05), and positively correlated with progesterone concentration (P <0.01). Research suggests that there is a cyclical change in serum PRL levels, which may be related to the interaction and regulation of trace elements. The physiological increase of PRL in mid-luteal phase can promote the synthesis of progesterone and the maintenance of luteal function