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目的：为探讨骨质疏松症与ＮＯ、ＮＯＳ的关系。方法：将２０只１４月龄雌性大鼠随机分成Ａ、Ｂ两组，其中Ａ组（１０只）去势造成骨质疏松症模型，测定其血清中ＮＯ、ＮＯＳ的变化，与正常假手术组（Ｂ）进行对照。结果：发现去势模型组ＮＯ、ＮＯＳ水平明显低于正常假手术组（Ｐ＜０．０５）。结论：说明ＮＯ、ＮＯＳ参与了骨质疏松症病理生理过程
Objective: To explore the relationship between osteoporosis and NO and NOS. Methods: 20 14-month-old female rats were randomly divided into A and B groups. Group A (10 rats) castration induced osteoporosis model, serum NO and NOS levels were measured, compared with normal sham operation group (B) for comparison. Results: The levels of NO and NOS in castrated model group were significantly lower than those in normal sham operation group (P <0.05). Conclusion: NO and NOS are involved in the pathophysiological process of osteoporosis