论文部分内容阅读
目的比较三联与四联用药治疗幽门螺杆菌(Hp)感染儿童消化性溃疡的临床疗效。方法选取2013—2014年合江县人民医院收治的Hp感染消化性溃疡患儿82例,根据入院先后分为三联组40例和四联组42例。三联组给予三联疗法,四联组给予四联疗法。比较两组Hp根除情况、临床疗效、不良反应发生情况及复发情况。结果两组Hp根治率、总有效率、不良反应发生率、复发率比较,差异无统计学意义(P>0.05),四联组复发时间晚于三联组,差异有统计学意义(P<0.05)。结论三联药物方案治疗Hp阳性儿童消化溃疡和含铋剂的四联方案疗效相当,临床治疗时应从儿童用药的安全性出发,优先考虑三联方案。
Objective To compare the clinical efficacy of triple and quadruple drug treatment of peptic ulcer in children with Helicobacter pylori (Hp) infection. Methods Eighty-two children with Hp-infected peptic ulcer were enrolled in Hejiang County People’s Hospital from 2013 to 2014. They were divided into triple group (40 cases) and quadruple group (42 cases). Triple group triple therapy, quadruple group given quadruple therapy. Hp eradication, clinical efficacy, adverse reactions and recurrence were compared between the two groups. Results There was no significant difference in the radical cure rate, total effective rate, adverse reaction rate and relapse rate between the two groups (P> 0.05), and the recurrence time of the quadruple group was later than that of the triple group (P <0.05 ). Conclusions The triple drug regimen is effective in treating Hp-positive children with peptic ulcer and the bismuth-containing quadruple combined regimen. The clinical treatment should be based on the safety of children’s medication, giving priority to the triple regimen.