过去的研究证明,无机氟化物对于离体细胞是一种细胞毒剂,可导致细胞生长抑制与细胞死亡。其作用机理可能是氟抑制细胞的蛋白质合成。但是,发现在离体细胞培养基中,逐步递增氟的浓度进行长期培养,则这些细胞可演变成为抗氟细胞,可耐受比细胞致死剂量大若干倍的氟化物。为了研究活体内各种细胞接触一定浓度和 Previous studies have shown that inorganic fluoride is a cytotoxic agent for ex vivo cells and can lead to inhibition of cell growth and cell death. Its mechanism of action may be fluorine inhibits cellular protein synthesis. However, it has been found that, in a long-term culture of the gradual increase of the concentration of fluorine in ex vivo cell culture medium, these cells can evolve into anti-fluoride cells and tolerate fluorides several times larger than the cell lethal dose. In order to study the in vivo exposure of a variety of cells to a certain concentration and