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目的观察左氧氟沙星联合标准化疗方案治疗肺结核患者的疗效和安全性。方法采用随机配对分组,将70例初治结核病患者分为观察组35例和对照组35例。观察组使用左氧氟沙星,两组同时辅以其他相同抗结核药物治疗。结果治疗1个月后、2个月后,观察组痰菌阴转、病灶吸收、症状改善均明显高于对照组(P<0.05),治疗4个月后、5个月后两组有效率无显著差异(P>0.05),两组患者的不良反应发生率无显著性差异(P>0.05)。结论左氧氟沙星配合其他抗结核药具有良好的抗结核作用,可应用于各种类型的肺结核,安全、有效、不良反应小。
Objective To observe the efficacy and safety of levofloxacin combined with standard chemotherapy in the treatment of patients with pulmonary tuberculosis. Methods Randomized matching grouping was used to divide 70 patients with newly diagnosed tuberculosis into 35 cases in observation group and 35 cases in control group. The observation group used levofloxacin, both groups supplemented with other same anti-TB drugs. Results After 1 month and 2 months after treatment, the sputum negative conversion, lesion absorption and symptom improvement in the observation group were significantly higher than those in the control group (P <0.05). After 4 months of treatment, the efficiency of the two groups after 5 months There was no significant difference (P> 0.05). There was no significant difference in adverse reactions between the two groups (P> 0.05). Conclusion Levofloxacin in combination with other anti-TB drugs has a good antituberculous effect and can be used in various types of pulmonary tuberculosis. It is safe, effective and has little adverse reactions.