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目的 研究非细胞毒性化疗药物对胃癌生长的抑制作用及机制。方法 观察胃泌素受体（GR）拮抗剂对胃癌细胞株MKN45移植瘤生长的抑制作用;在测定34例胃癌患者达GR的基础上,对GR阳性的胃癌患者加用丙谷胺（PGL）,评价其初步临床效果。结果PGL组移植面积、重量、胃癌细胞 DNA指数、DNA含量及S期细胞比例均低于对照组,PGL+SST组更低;晚期胃体癌、胃底贲门癌易于表达GR;对14例GR阳性的胃癌患者随访16～21月,对照组8例患者中有2例死亡,PGL组6例均存活。结论PGL能调控胃癌细胞株MKN45移植瘤的生长,有望能改善胃癌患者的预后。
Objective To study the inhibitory effect and mechanism of non-cytotoxic chemotherapy drugs on gastric cancer growth. Methods The inhibitory effects of gastrin receptor (GR) antagonists on the growth of gastric cancer cell line MKN45 were observed. Prolactin (PGL) was added to GR positive gastric cancer patients based on the measurement of GR in 34 patients with gastric cancer. , evaluate its preliminary clinical effect. Results The graft area, weight, gastric cancer cell DNA index, DNA content and S-phase cell ratio in PGL group were lower than those in control group, and PGL+SST group was lower. Late gastric cancer and gastric cardia cancer were easy to express GR; Positive gastric cancer patients were followed up from 16 to 21 months. In the control group, 2 of 8 patients died, and 6 patients in the PGL group survived. Conclusion PGL can regulate the growth of gastric cancer cell line MKN45, which may improve the prognosis of gastric cancer patients.