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目的 探讨老年冠心病患者红细胞免疫功能与脂蛋白 (a)的变化。方法 将老年冠心病人 ( 49例 )分为不稳定型心绞痛组 ( 2 7例 )和稳定型心绞痛组 ( 2 2例 ) ,并与 46例健康老人对比。采用“郭峰改良法”及免疫比浊法分别检测三组的红细胞C3b受体花环率 (RBC C3bRR)、红细胞免疫复合物花环率 (RBC ICR)及脂蛋白 (a) [Lp(a) ]。 结果 老年冠心病两亚组RBC C3bRR与对照组比较 ,无显著性差异 (P >0 .0 5 )。RBC ICR及Lp(a)均明显高于对照组 (P <0 .0 1) ,尤以不稳定型心绞痛组为甚。Lp(a)与RBC ICR间有明显的相关性 (r =0 .6 6 ,P <0 .0 1)。 结论 RBC ICR、Lp(a)的增高与冠心病密切相关。
Objective To investigate the changes of erythrocyte immune function and lipoprotein (a) in elderly patients with coronary heart disease. Methods Aged patients with coronary heart disease (49 cases) were divided into unstable angina (27 cases) and stable angina (22 cases), and compared with 46 healthy elderly. The RBC C3bRR, RBC ICR and Lp (a) [Lp (a)] of erythrocytes were detected in three groups by “Guo Feng Modified Method” and immunoturbidimetry. Results There was no significant difference in RBC C3bRR between two subgroups of elderly patients with coronary heart disease (P> 0.05). RBC ICR and Lp (a) were significantly higher than those in control group (P <0.01), especially in unstable angina group. There was a significant correlation between Lp (a) and RBC ICR (r = 0.66, P <0.01). Conclusion The elevated RBC ICR and Lp (a) are closely related to coronary heart disease.