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随着现代医学、分子生物学研究的不断进步以及肿瘤相关疾病的发病率逐年增高,几种遗传性癌症综合征近年越来越引起人们的关注。遗传性癌症综合征与基因突变所致早熟终止密码子(premature termination codon,PTC)有关。PTC与正常翻译的终止密码子结构相同,正常的终止密码子可以终止整个翻译过程,但PTC有时会有氨基酸替代其位置,形成自然的PTC的通读(readthrough),合成长度
With the progress of modern medicine and molecular biology research and the increasing incidence of cancer-related diseases, several hereditary cancer syndromes have drawn more and more attention in recent years. Hereditary cancer syndrome is associated with premature termination codon (PTC) due to genetic mutation. PTC has the same stop codon structure as normal translation, and normal stop codons can stop the entire translation process, but sometimes PTCs have amino acid substitutions for their positions to form natural PTC readthroughs, synthetic lengths