越来越多的证据表明,胰岛素抵抗可能是Ⅱ型糖尿病的主要原因,胰岛素相对不足被认为系代偿失调所致。其显著遗传性已被公认。是否胰岛素绝对不足和胰岛素抵抗二者无关联;如果胰岛素绝对不足(Ⅰ型糖尿病)和遗传性胰岛素抵抗(Ⅱ型糖尿病)合并存在时则出现混合型糖尿病。作者认为存在混合型糖尿病(称为 Ic 型),并通过前瞻性研究证实了这种假设。 There is growing evidence that insulin resistance may be a major cause of type 2 diabetes and that the relative lack of insulin is considered to be due to decompensation. Its remarkable heritability has been recognized. There is no association between absolute insulin deficiency and insulin resistance, and mixed diabetes if combined with absolute insulin deficiency (type I diabetes) and hereditary insulin resistance (type II diabetes). The authors concluded that there was mixed diabetes (called type Ic) and confirmed this hypothesis through a prospective study.