论文部分内容阅读
抗凋零基因Ｂｃｌ－２可抑制细胞凋零，促进细胞增殖，与部分肿瘤的发生相关。作者利用免疫组织化学技术观察了２６例口腔粘膜相关性淋巴瘤中Ｂｃｌ－２基因产物的表达，以探讨Ｂｃｌ－２表达与该肿瘤组织类型、免疫表型等之间的关系。结果表明，２６例口腔粘膜相关性淋巴瘤中，７３％的病例Ｂｃｌ－２产物阳性。在三种主要组织类型中，小裂细胞样淋巴瘤阳性率最高（８３％），其次为浆细胞样淋巴瘤（７１％）和浆细胞性淋巴瘤（５１％），相互间差异有显著性（Ｐ＜０．０１）。在可进行免疫分型的２０例中，Ｂ细胞淋巴瘤、Ｔ细胞淋巴瘤及不可分类淋巴瘤的Ｂｃｌ－２产物阳性率依次分别为６９％、７５％和８３％（Ｐ＜０．０１）。结果提示，细胞自然凋零过程的抑制可能是部分口腔粘膜相关性淋巴瘤的发生原因之一。
The anti-border gene Bcl-2 can inhibit cell decline and promote cell proliferation, which is related to the occurrence of some tumors. The authors used immunohistochemical techniques to observe the expression of Bcl-2 gene products in 26 cases of oral mucosa-associated lymphomas to investigate the relationship between Bcl-2 expression and the tumor tissue type and immunophenotype. The results showed that in 26 cases of oral mucosa-associated lymphoma, Bcl-2 production was positive in 73% of cases. Among the three major tissue types, the highest positive rate of small-split cell-like lymphoma (83%) was followed by plasma cell-like lymphoma (71%) and plasma cell lymphoma (51%), with significant differences between them. (P<0.01). Of the 20 cases that could be immunophenotyped, the positive rates of Bcl-2 production in B-cell lymphomas, T-cell lymphomas, and unclassifiable lymphomas were 69%, 75%, and 83%, respectively (P<0.01). . The results suggest that the inhibition of the natural withering process may be one of the causes of some of the oral mucosa-associated lymphomas.