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目的 以迷走神经为对象 ,研究胆管加压所致机体心血管活动变化的神经机理。方法 采用自制“盲囊”导管制成家兔急性胆管加压模型 ,观察动物的动脉血压及心输出量改变情况。结果 持续胆道加压 ,家兔的动脉血压和心输出量几乎平行快速下降 (P <0 .0 5 ) ;这种变化在阻断颈部或腹部迷走神经后 ,又很快恢复至加压前水平 (P >0 .0 5 ) ,但动脉血压和心输出量的恢复速度 ,按迷走神经的阻断部位不同而有所差异。结论 胆道高压所致的家兔血液动力学变化 ,与迷走神经的活动有关 ,并且推断可能是一种神经反射机制。
Objective To study the neural mechanism of cardiovascular activity in the vagus nerve caused by bile duct compression. Methods A rabbit model of acute bile duct compression was made by homemade “blind sac” catheter to observe the changes of arterial blood pressure and cardiac output. Results Continuous biliary pressure was applied, and the arterial blood pressure and cardiac output of rabbits decreased rapidly and almost parallel (P <0.05). This change quickly returned to pre-stress level after blocking the vagus nerve of the neck or abdomen (P> 0.05). However, the recovery rate of arterial blood pressure and cardiac output differed according to the location of vagal nerve block. Conclusions The hemodynamic changes in rabbits caused by biliary tract hypertension are related to vagal activity and may be a neuroreflective mechanism.