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从糙皮侧耳真菌（Ｐ．Ｏｓｔｒｅａｔｔｕｓｆｕｎｇ）中提取出糖肽（Ｐ．ＯｓｔｒｅａｔｕｓＧｌｙｃｏｐｅｐｔｉｄｅｓ，ＰＯＧＰ）。体内、外实验表明，ＰＯＧＰ有促进ＬＡＫ和ＮＫ细胞杀伤瘤细胞的作用；药理实验显示有抑制小鼠Ｓ１８０瘤细胞增殖和向周围组织侵袭的作用；病理检测可见ＰＯＧＰ能引起瘤组织坏死，淋巴细胞浸润，并形成较厚的纤维包膜。提示ＰＯＧＰ具有使肿瘤组织纤维化的作用。
Glycoopeptides (POGP) were extracted from Pleurotus ostreatus fungus (P. Ostreattusfung). In vitro and in vivo experiments showed that POGP could promote the killing of tumor cells by LAK and NK cells. Pharmacological experiments showed that POGP could inhibit the proliferation and invasion of S180 tumor cells in peripheral tissues. Pathological examination showed that POGP could induce tumor necrosis and lymphocyte Infiltration, and the formation of thicker fibrous envelope. Tip POGP has the role of tumor tissue fibrosis.