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为研究东亚钳蝎毒灌肠治疗大肠癌前后肿瘤组织中DNA参数的变化,采用CMIAS真彩色医学图像分析系统对20例大肠癌患者用东亚钳蝎毒灌肠治疗后肿瘤细胞核DNA参数测定,结果发现:①DNA指数均值(DI):治疗前DI值1.92±0.19。治疗后DI值1.58+0.24,治疗后同治疗前比较DI值明显缩小(P<0.01)。②DNA倍体类型的分布:治疗后与治疗前比较,≥5倍体明显减少,二倍体明显增多(P<0.05)。③细胞核形态参数:治疗后与治疗前比较,细胞核面积的均值,核周长的均值和细胞浆面积均值明显减少,有显著性差异(P<0.05)。同期随机选10例直肠癌患者用氟脲嘧啶灌肠,治疗前后各参数值虽有变化,但无统计学意义(P>0.05)。说明东亚钳蝎毒对大肠癌有抑杀作用,且优于氟脲嘧啶。
In order to study the changes of DNA parameters in colorectal tumor before and after treatment with colorectal cancer enema, the CMIAS true color medical image analysis system was used to determine the nuclear DNA parameters of 20 patients with colorectal cancer after treatment with East Asia forceps enema. The results showed that: 1Mean value of DNA index (DI): DI value before treatment was 1.92±0.19. After treatment, the DI value was 1.58+0.24, and the DI value was significantly reduced after treatment compared with before treatment (P<0.01). 2 Distribution of DNA ploidy type: Compared with pre-treatment, ≥5-ploid was significantly reduced and diploid was significantly increased (P<0.05). 3Nucleus morphological parameters: Compared with before treatment, the average of nuclear area, the average of nuclear perimeter and the mean cell area were significantly reduced, with significant differences (P<0.05). At the same time randomly selected 10 patients with rectal cancer with fluorouracil enema, although the parameters before and after treatment values change, but no statistical significance (P> 0.05). It was demonstrated that C. jasminoides has an inhibitory effect on colorectal cancer and is superior to fluorouracil.