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在我国,大部分恶性肿瘤患者确诊时已为晚期或伴远处转移,目前单一化学治疗方法效果不理想,肿瘤常常会在短的时间内复发,这可能是由于化疗期间肿瘤细胞的加速再增殖所致。众所周知,若没有血液供应,肿瘤细胞由于缺血缺氧会发生死亡,肿瘤尺寸不会超过2～3 mm3。因此,在化疗间期肿瘤细胞加速再增殖过程中,给予抗血管生成治疗可抑制残存肿瘤细胞的再增殖,达到提高化疗药物治疗效果,延缓疾病进展的目的。
In our country, the majority of malignant tumor patients have been diagnosed late or with distant metastasis, the current single chemotherapy is not effective, the tumor often recur in a short period of time, which may be due to chemotherapy during the accelerated proliferation of tumor cells Due. It is well-known that in the absence of blood supply, tumor cells die as a result of ischemia and hypoxia, and tumor sizes do not exceed 2 to 3 mm3. Therefore, during the period of accelerated chemotherapy and re-proliferation of tumor cells, anti-angiogenic therapy can inhibit the re-proliferation of residual tumor cells to achieve the goal of improving the therapeutic effect of chemotherapy drugs and slowing the progression of the disease.