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成熟、有活性的树突状细胞 (DCs)对于活化的肿瘤特异性淋巴细胞在致癌过程中的再生和存活是至关重要的。肝细胞癌 (HCC)和肝硬化 (LC)患者的外周血中CD83阳性的DCs的浓度几乎是相同的。就肝组织而言 ,与LC相比 [(6 6± 10 9)比 (33 3± 2 4 )个DCs 组织切片 ,P <0 0 5 ) ],HCC中的CD83阳性的DCs却明显减少。更重要的是 ,HCC癌结节中完全缺乏CD83阳性的DCs。本研究初步探讨了在HCC的发病机制中肝内浸润的有活性的DCs的作用
Mature, active dendritic cells (DCs) are crucial for the regeneration and survival of activated tumor-specific lymphocytes during carcinogenesis. The concentration of CD83-positive DCs in the peripheral blood of patients with hepatocellular carcinoma (HCC) and cirrhosis (LC) is almost the same. For liver tissue, CD83-positive DCs were significantly reduced in HCC compared with [(6 6 ± 10 9) vs (33 3 ± 2 4) DCs tissue sections, P 0 05). More importantly, CD83-positive DCs are completely absent in HCC cancerous nodules. This study explored the role of intrahepatic infiltration of active DCs in the pathogenesis of HCC