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Objective:To investigate the effect of aqueous solution of Biophytum sensUiuum leaf extract(BSEt)on normal and strcptozotocin(STZ)-nicotinamide-induced diabetic rats.Methods:Diabetes was induced in adult male Wislar rata by the administration of STZ-nicotinamide(40,110 mg/kg b.w.,respectively)intraperitoneally.BSEt(200 mg/kg)was administered to diabetic rats for 28 days.The effect of extract on blood glucose,plasma insulin,total haemoglobin,glycosylated haemoglobin,liver glycogen and carbohydrate melatxilism regulating enzymes of liver was studied in diabetic rats.Results:BSEt significantly reduced the blood glucose and glycosylated haemoglobin levels and significantly increased the total haemoglobin,plasma insulin and liver glycogen levels in diabetic rats.It also increased the hexokinase activity and decreased glucose-6-phosphatase,fructose-1,6-bisphosphatase activities in diabetic rats.Conclusions:The results of our study suggest that BSEt possesses a promising effecl on STZ-nicotinamide-induced diabetes.
Objective: To investigate the effect of aqueous solution of Biophytum sensuiuum leaf extract (BSEt) on normal and strcptozotocin (STZ) -nicotinamide-induced diabetic rats. Methods: Diabetes was induced in adult male Wislar rata by the administration of STZ-nicotinamide (40, 110 The effect of extract on blood glucose, plasma insulin, total hemoglobin, glycosylated hemoglobin, liver glycogen and carbohydrate melatxilism regulating enzymes of liver was studied in diabetic rats. Results: BSE significantly reduced the blood glucose and glycosylated haemoglobin levels and significantly increased the total hemoglobin, plasma insulin and liver glycogen levels in diabetic rats. Also also increased the hexokinase activity and decreased glucose-6-phosphatase, fructose-1,6-bisphosphatase activities in diabetic rats. Conclusions: The results of our study suggest that BSEt possesses a promising effecl on STZ-nicotin amide-induced diabetes.