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目的:观察气道正压通气(CPAP)治疗对睡眠呼吸暂停综合征(OSAS)合并2型糖尿病和高血压患者的动态血糖、动态血压影响。方法:采用动态血糖监测系统对16例OSAS合并2型糖尿病和高血压患者进行连续72 h血糖监测;第1天同时应用多导睡眠仪监测并诊断OSAS严重程度;第1天和第3天行24 h动态血压监测。结果:CPAP治疗2 d后,OSAS合并高血压患者的夜间收缩压和舒张压均下降,差异无统计学意义。日间和夜间血糖无明显变化。结论:CPAP长期治疗的2型糖尿病伴发OSAS患者胰岛素抵抗改善,血糖水平降低,血糖变化规律可能与患者糖尿病的严重程度、胰腺B细胞功能、OSAS严重程度等多种因素相关。
Objective: To observe the effects of positive airway pressure (CPAP) on the dynamic blood pressure and ambulatory blood pressure in patients with sleep apnea syndrome (OSAS) complicated by type 2 diabetes and hypertension. Methods: Sixty-two OSAS patients with type 2 diabetes mellitus and essential hypertension underwent continuous 72-hour blood glucose monitoring using a dynamic glucose monitoring system. On the first day, polysomnography was used to monitor and diagnose the severity of OSAS. Day 1 and day 3 24 h ambulatory blood pressure monitoring. Results: After 2 days of CPAP treatment, the systolic and diastolic blood pressure of patients with OSAS complicated with hypertension decreased at night, the difference was not statistically significant. No significant changes in blood glucose during the day and night. Conclusion: Long-term treatment of type 2 diabetes mellitus patients with type 2 diabetes mellitus with OSAS improved insulin resistance, blood glucose levels, blood glucose changes may be related to the severity of diabetes, pancreatic B cell function, OSAS severity and other factors.