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肝硬化的顽固性腹水单用安体舒通常不能取得满意效果,用量超过200～300毫克,利尿作用并不增强。最近有人报告单用大剂量安体舒通有效。为此作者研究用大剂量安体舒通的利尿效果及其副作用。 10例慢性肝病顽固性腹水患者(未用利尿剂的基础尿钠为5毫克当量/升,用双氢克尿噻效果不好,尿钠少于30毫当量/升),单用安体舒通每目300～600毫克,观察利尿作用及血液生化变化和副作用。
Cirrhosis refractory ascites alone Anshube generally can not get satisfactory results, the amount of more than 200 to 300 mg, diuretic effect is not enhanced. Recently, it was reported that the single dose of spironolactone effective. To this end, the author studied the use of large doses of spironolactone diuretic effect and its side effects. 10 cases of chronic liver disease patients with refractory ascites (not based on diuretic natriuretic sodium 5 mg equivalent / l with dihydrotestosterone not good, urinary sodium less than 30 milliequivalents / l), only with spironolactone Through 300 ~ 600 mg per head, to observe diuretic effects and blood biochemical changes and side effects.