论文部分内容阅读
目的：探讨性激素及其受体改变与慢性肾炎及尿毒症病因及发病机理的联系。方法：应用放射配体结合法检测慢性肾炎６３例及尿毒症１０１例患者外周血白细胞雄激素受体（ＡＲ）及雌激素受体（ＥＲ）。结果：（１）慢性肾炎患者白细胞ＡＲ测定结果显示男性、育龄女性及绝经女性３组与对照组比无显著性差异。（２）慢性肾炎患者白细胞ＥＲ测定结果显示上述３组明显高于对照组（Ｐ＜０．０１）。（３）尿毒症患者白细胞ＡＲ测定结果显示３组均明显低于对照组（均Ｐ＜０．０５）。（４）尿毒症患者白细胞ＥＲ测定结果显示３组明显高于对照组（Ｐ＜０．０５或Ｐ＜０．０１）。结论：慢性肾炎及尿毒症患者白细胞ＥＲ的结合容量明显升高；尿毒症患者白细胞ＡＲ降低。提示ＥＲ及ＡＲ的改变导致性激素功能的改变，与慢性肾炎及尿毒症的病理变化有一定关联。
Objective: To investigate the relationship between sex hormones and their receptors changes and etiology and pathogenesis of chronic nephritis and uremia. Methods: Radioligand binding assay was used to detect the levels of androgen receptor (AR) and estrogen receptor (ER) in 63 patients with chronic nephritis and 101 patients with uremia. Results: (1) The results of leukocyte AR measurement in patients with chronic nephritis showed no significant difference between male, female of childbearing age and 3 of menopausal women compared with the control group. (2) The results of leukocyte ER in patients with chronic nephritis showed that the above three groups were significantly higher than the control group (P <0.01). (3) The results of leukocyte AR assay in uremic patients showed that the three groups were significantly lower than the control group (all P <0.05). (4) The result of leukocyte ER in uremia patients showed that the three groups were significantly higher than the control group (P <0.05 or P <0.01). Conclusion: The binding capacity of leukocyte ER in patients with chronic nephritis and uremia is obviously increased. The AR of leucocytes in patients with uremia is decreased. Prompted changes in ER and AR lead to changes in sex hormone function, and chronic nephritis and uremia are related to the pathological changes.