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近年来对血小板功能的研究,提示与血管病有直接关系。本文应用血液流变学及放免法测定74例原发性高血压患者血小板粘附、聚集率和TXB_2、6-酮-PGF_(1a)(以下简称6-酮)的含量,结果分析如下。 1 对象与方法 1.1 对象 原发性高血压组74例,男56例,女18例;年龄:45～68岁,平均年龄59.8岁。均为住院及干休所病例,检查前停药两周。经检查排除了继发性高血压,随机测血压≥21.3/12.6kpa二次以上,按WHO分期均属Ⅱ期。对照组74例,男54例,女20例;年龄45～65岁,平均年龄57.6岁。经临床检查无高血压、冠心病、糖尿病等慢性病。脑电图、血脂、血糖、眼底检查均正常。采血前二周以上未用药物。进行了血浆TXB_2、6-酮含量测定,其中50例同时检测了血小板粘附、聚集率。
In recent years, the study of platelet function, suggesting that vascular disease is directly related. In this paper, hemorheology and radioimmunoassay 74 patients with essential hypertension platelet adhesion, aggregation rate and TXB_2.6-keto-PGF_ (1a) (hereinafter referred to as 6-ketone) content, the results are as follows. 1 Subjects and Methods 1.1 Object 74 cases of essential hypertension group, 56 males and 18 females; aged 45 to 68 years, mean age 59.8 years old. All hospitalized and dry-rest cases, withdrawal two weeks before the test. After examination ruled out secondary hypertension, random blood pressure ≥ 21.3 / 12.6kpa more than two, according to WHO stage are Ⅱ. Control group, 74 cases, 54 males and 20 females; aged 45 to 65 years, mean age 57.6 years. After clinical examination without hypertension, coronary heart disease, diabetes and other chronic diseases. EEG, blood lipids, blood glucose, fundus examination were normal. Two weeks before blood collection unmedicated. Plasma TXB_2, 6-Ketone levels were measured, of which 50 cases simultaneously detected platelet adhesion and aggregation rate.