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【目的】分析上消化道出血与急性脑梗死之间的关系。【方法】对本院2010年7月至2014年8月收治的18例上消化道出血并发急性脑梗死患者的临床特点进行分析。【结果】本组18例患者的平均年龄为61岁。其中消化性溃疡占10例(55.6%)，肝硬化5例(27.7%)。同时伴有高血压、高血脂及糖尿病等与动脉硬化有关的因素占14例(77.8%)；12例(66.7%)有不同程度的吸烟史，出现脑梗死的时间平均为上消化道出血后的3.4 d；15例(83.3%)患者使用了抗纤溶药。同时根据缺血性卒中的 CISS 分型发现：大动脉型中低灌注/栓子清除下降亚型共8例(44.4%)，动脉到动脉栓塞4例(22.2%)，穿支动脉闭塞3例(16.7%)，心源性栓塞3例(16.7%)。【结论】对于老年人并伴有与动脉硬化有关的因素的疾病，且既往有消化性溃疡史的患者，出现上消化道出血后3 d 左右并发急性脑梗死的概率最高，有大血管病变的患者尤为明显。医护人员应当认识到该类危险，在治疗时禁用或慎用抗纤溶药，并维持适当的血压，保证脑灌注。“,”[Objective]To explore the relationship between upper gastrointestinal hemorrhage and acute cere-bral infarction.[Methods]From July 2010 to August 2014,the clinical data were analyzed for 18 cases of upper gastrointestinal hemorrhage complicated with acute cerebral infarction.[Results]Their mean age was 61 years. There were peptic ulcer (n =10,55.6%),cirrhosis (n =5,27.7%),hypertension,high cholesterol and diabe-tes associated with atherosclerosis (n =14,77.8%)and a history of smoking (n =12,66.7%).And cerebral in-farction occurred after 3.4 days of upper gastrointestinal hemorrhage.And 1 5 cases (83.3%)used antifibrinolytic drugs.According to the Chinese Ischemic Stroke Subclassification (CISS),the types were main artery hypoperfu-sion or emboli clearing decline (n =8,44.4%),artery-to-artery embolization (n =4,22.2%),perforating arter-y occlusion (n =3,1 6.7%)and cardiogenic embolization (n =3,1 6.7%).[Conclusion]For elders with athero-sclerotic factors and a previous history of peptic ulcer,acute cerebral infarction may occur around 3 days of upper gastrointestinal hemorrhage.And a large vessel disease is particularly evident.Physicians should raise a high alert. Antifibrinolytic agents are cautiously used.And proper blood pressure and cerebral perfusion are maintained.