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目的:考察盆炎清灌肠剂的抗炎、镇痛、抑菌、活血化瘀作用。方法:以对子宫塑料管所致大鼠子宫炎症肿胀程度,考察其抗炎作用;以光热刺激鼠尾—逃避法,考察其镇痛作用;含药血清体外抑菌法检测其抑菌作用;以肾上腺素引起微循环障碍造成大鼠血瘀模型,研究其活血化瘀作用。结果:实验证明盆炎清灌肠剂有明显的抑制大鼠子宫炎症肿胀作用(P<0.05);具有明显的抑制大鼠光热刺激鼠尾的逃避时间(P<0.01);含药血清体外抑菌试验证实其对金黄色葡萄球菌有一定的抑菌作用。结论:盆炎清灌肠剂的药效与临床治疗慢性盆腔炎疗效相一致。
Objective: To investigate the anti-inflammatory, analgesic, antibacterial, and blood circulation effects of Pan Yan Qing Enema. Methods: The degree of inflammation of rat uterus induced by uterine plastic tube was examined. The anti-inflammatory effect was investigated. The analgesic effect was investigated by photothermal stimulation of rat tail-escape method. The antibacterial effect of drug-containing serum was tested by in vitro antibacterial method. The rat model of blood stasis caused by epinephrine-induced microcirculatory disturbances was studied. Results: The experiment showed that Panyanqing enema had obvious effect in inhibiting the inflammation and swelling of rat uterus (P<0.05); it had obvious inhibition time of photothermal stimulation of rat tail in rats (P<0.01); The bacteria test confirmed its antibacterial activity against Staphylococcus aureus. Conclusion: The efficacy of Panzhiqing enema agent is consistent with the clinical efficacy of chronic pelvic inflammatory disease.