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目的：观察ｐ５３蛋白表达能否作为判断胃癌病人的预后指标，为该指标的合理应用提供科学依据。方法：利 用免疫组化技术检测１７１例胃癌切除标本内ｐ５３蛋白的表达，分析ｐ５３蛋白表达与临床病理及预后之间的关系，探讨 ｐ５３蛋白表达与传统ＴＮＭ分期在预测预后中的关系。结果：４３．３％的胃癌组织有ｐ５３蛋白表达，弥漫型胃癌中的 ｐ５３蛋白表达率高于肠型胃癌（Ｐ＜０.０５）；有ｐ５３蛋白表达的胃癌组织易于发生淋巴结转移（Ｐ＜００５）；有ｐ５３蛋白表 达的胃癌病人预后差（Ｐ＜０．０１）。结论：ｐ５３蛋白对推测的胃癌病人淋巴结转移率及判断预后十分有益，将ｐ５３蛋白 表达与经典的ＴＮＭ分期结合，使该指标的应用更具科学性。
Objective: To observe whether p53 protein expression can be used as a prognostic indicator of gastric cancer patients and provide a scientific basis for its reasonable application. Methods: The expression of p53 protein in 171 specimens of gastric cancer was detected by immunohistochemistry. The relationship between p53 protein expression and clinical pathology and prognosis was analyzed. The relationship between p53 protein expression and traditional TNM staging in predicting prognosis was analyzed. Results: p53 protein was expressed in 43.3% of gastric cancer tissues and p53 protein in diffuse gastric cancer tissues was higher than that of intestinal type gastric cancer (P <0.05). Lymph node metastasis was more likely in gastric cancer tissues with p53 protein expression (P < 005). The prognosis of gastric cancer patients with p53 protein expression was poor (P <0.01). CONCLUSION: The p53 protein is very useful for predicting the lymph node metastasis rate and prognosis in patients with gastric cancer. The combination of p53 protein expression and classic TNM staging makes the application of this indicator more scientific.