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抗磷脂抗体与反复流产有关。资料显示肝素可治疗反复流产,但肝素对抗磷脂抗体的影响知之甚少。为了解肝素治疗者妊娠中和分娩后血清抗磷脂抗体的变化及与当次和以后妊娠结局的关系设计该项前瞻性研究。 研究对象为1993年6月～1998年5月期间自发性流产≥3次的妇女36例,平均年龄34.1(21～42)岁,无导致流产的其它原因,狼疮抗凝和抗心磷脂抗体阳性。狼疮抗凝因子阳性的标准是:稀释凝血酶原时间(PT)高于正常对照水平,稀释活化部分凝血活酶时间(PTT)高于正常对照的2倍。抗心磷脂抗体阳性的标准是:ELISA方法测定IgG和IgM抗体≥1.0U/ml。就诊后一经诊断为妊娠即开始肝素治疗。肝素
Antiphospholipid antibodies and recurrent miscarriage. Data show that heparin can treat recurrent miscarriage, but little is known about the effect of heparin on antiphospholipid antibodies. This prospective study was designed to understand the changes of serum anti-phospholipid antibodies during pregnancy and after delivery in heparin-treated patients and the relationship between the current and future pregnancy outcomes. Thirty-six women with spontaneous abortion≥3 were selected from June 1993 to May 1998. The mean age was 34.1 (21-42) years. There were no other causes of miscarriage. The positive rates of lupus anticoagulant and anticardiolipin antibodies . The criteria for a positive lupus anticoagulant were: dilution of prothrombin time (PT) above normal control level, and dilution of activated partial thromboplastin time (PTT) 2-fold higher than normal controls. Anti-cardiolipin antibody positive criteria are: ELISA method for the determination of IgG and IgM antibodies ≥ 1.0U / ml. Once diagnosed with pregnancy, heparin treatment begins. heparin