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1990年以来,Oberhausen基督教医院对第12～14孕周的1100例孕妇常规做了早期羊膜穿刺术。先经超声检查羊水分布、羊水量、胎盘位置,并确定可行的穿刺部位。在超声持续监护下,用20Gauge脊髓针穿刺,同天还进行遗传学方面的羊水检查。 细胞遗传学结果,2.6％(29/1100)有核型异常:9例21-三体,1例18-三体,1例13-三体,3例克氏综合征,1例三倍体,4例单体性X或嵌合单体性X,1例嵌合性18单体及9例结构改变。 穿刺1次者1062例,2次者34例,3次者4
Since 1990, Oberhausen Christian Hospital has routinely performed early amniocentesis on 1,100 pregnant women between the 12th and 14th gestational weeks. First, the amniotic fluid ultrasound examination, amniotic fluid volume, placental location, and determine the feasible puncture site. Under continuous ultrasound monitoring, needle puncture with 20Gauge spinal cord, the same day also carried out genetically modified amniotic fluid examination. Cytogenetics results showed karyotype abnormalities in 2.6% (29/1100): 9 cases of 21-trisomy, 1 case of 18-trisomy, 1 case of 13-trisomy, 3 cases of Klinefelter’s syndrome and 1 case of triploid , 4 cases of monomeric X or chimerism X, 1 case of chimeric 18 and 9 cases of structural changes. There were 1062 cases of puncture once, 34 cases twice, and 4 cases of three times