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目的探讨丹参酮ⅡA磺酸钠(STS)对大剂量电离辐射小鼠生存率的影响。方法小鼠一次性接受11Gy的60Co照射,分为生理盐水对照组和50 mg/kg、75 mg/kg和100 mg/kg3个STS剂量组,于照射前1 h和照射后0.5 h和24 h腹腔注射生理盐水或STS。结果照射后小鼠停止生长,照射后第7天75 mg/kg组小鼠体质量(20.3±2.2 g)显著高于对照组(17.6±1.8 g)(P<0.05)。小鼠的存活天数随STS注射剂量的增加依次为(9.5±1.5)d、(10.1±1.1)d、(10.5±1.2)d和(11.5±1.0)d。生存曲线分析显示,100 mg/kg组小鼠的生存率显著高于对照组和50 mg/kg组(均P<0.01)。结论 100 mg/kg STS注射后明显提高了大剂量电离辐射暴露后小鼠的生存质量和生存率。
Objective To investigate the effect of sodium tanshinone Ⅱ A sulfonate (STS) on the survival rate of high dose ionizing radiation mice. Methods The mice received 11Gy 60Co irradiation once and were divided into normal saline control group and 3 STS dose groups of 50 mg / kg, 75 mg / kg and 100 mg / kg, respectively. The mice were sacrificed at 1 h before irradiation and at 0.5 h and 24 h Intraperitoneal injection of saline or STS. Results After irradiation, the mice stopped growing. The body weight of mice in the 75 mg / kg group on day 7 after irradiation was significantly higher than that of the control group (20.3 ± 2.2 g, P <0.05). The number of mice surviving with STS injection was (9.5 ± 1.5) d, (10.1 ± 1.1) d, (10.5 ± 1.2) d and (11.5 ± 1.0) d, respectively. Survival curve analysis showed that the survival rate of 100 mg / kg group was significantly higher than that of control group and 50 mg / kg group (all P <0.01). Conclusion After 100 mg / kg STS injection, the quality of life and survival rate of mice after exposure to high doses of ionizing radiation were significantly increased.