视网膜母细胞瘤(RB)是视网膜细胞缺乏功能性RB基因时诱发的小儿眼部肿瘤,近来研究表明:腺病毒、乳头状病毒,BK和JC多瘤病毒的转化蛋白能和RB基因产物结合,而且腺病毒12(Ad12)、JCK类人猿病毒SV40在啮齿动物中可诱发RB样肿瘤,鉴于以上发现,作者应用PCR技术对50例RB患者检测五种人DNA肿瘤病毒:Ad12、BKV、JCV、HPV16、HPV18,但未检测到这些病毒序列,试验结果表明:目前尚未有证据证实这些病毒是人RB的病因。人们认为当二个RB等位基因经过突变或丢失后才诱发肿瘤。遗传型RB,小儿遗传一个缺损性RB等位基因,在100百万正在发育的视网膜细胞中第二个等位基因的突变率很高足以导致多灶性双眼肿瘤发生,但只有 Retinoblastoma (RB) is a retinal pigment epithelium that is induced in retinal cells lacking a functional RB gene. Recent studies have shown that the transformed proteins of adenovirus, papilloma virus, BK and JC polyoma can bind to the RB gene product, In addition, adenovirus 12 (Ad12) and JCK-like simian virus SV40 can induce RB-like tumors in rodents. In view of the above findings, the authors used PCR to detect five human DNA tumor viruses in 50 RB patients: Ad12, BKV, JCV, HPV16 , HPV18, but no detection of these virus sequences, the test results show that: there is no evidence that these viruses are the cause of human RB. It is thought that tumors are induced only after two RB alleles have been mutated or lost. Genetic RB, a pedigree with a defective RB allele, has a high mutation rate of the second allele in 100 million developing retinal cells sufficient to cause multifocal binocular tumors but only