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应用比色法测定了３４例胃癌患者血清和组织粘膜的一氧化氮（ＮＯ）含量，并设３０例正常人及３０例球部溃疡为血清对照组。２３例组织对照组系取自癌旁组织（肉眼和病理均属正常）。结果显示胃癌患者血清一氧化氮水平明显低于正常对照组及十二指肠球溃疡组（Ｐ＜０．０１）；而十二指肠球溃疡组则明显高于正常对组（Ｐ＜０．０１），胃癌组织中ＮＯ含量则显著高于癌旁组织（Ｐ＜０．０１）。研究表明当肿瘤发生时，经诱导活化的巨噬细胞可以产生大量的ＮＯ於病灶组织中而发挥其免疫功能，即ＮＯ直接作用于肿瘤细胞，启动机体其他免疫防御系统而杀伤肿瘤细胞并在粘膜损伤时有重要的修复功能。故而表现出血中ＮＯ水平下降，而胃癌组织局部ＮＯ水平升高。
The colorimetric method was used to determine the levels of nitric oxide (NO) in serum and tissue mucosa of 34 patients with gastric cancer. Thirty normal subjects and 30 patients with spherical ulcers were used as serum control group. Twenty-three tissue control groups were obtained from adjacent tissues (normal to the naked eye and pathology). The results showed that serum nitric oxide levels in patients with gastric cancer were significantly lower than those in normal controls and duodenal ulcers (P<0.01), while those in duodenal ulcers were significantly higher than those in normal controls (P<0). .01) The NO content in gastric cancer was significantly higher than that in the paracancerous tissues (P<0.01). Studies have shown that when tumors are induced, activated macrophages can produce a large amount of NO in the lesion tissue and exert their immune function, that is, NO directly acts on tumor cells, starts the body’s other immune defense system and kills tumor cells and in the mucosa. There is an important repair function when damaged. As a result, the level of NO in the hemorrhage decreased, while the level of NO in the gastric cancer tissue increased.