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目的 探讨影响Ⅳ期上皮性卵巢癌预后的因素。方法 回顾性分析 1990年 1月～ 1998年 5月我院治疗的 31例Ⅳ期上皮性卵巢癌的临床资料 ,包括患者年龄、病理类型、分化程度、转移部位、术后残留病灶大小、化疗疗程数及生存期等。结果 总的中位生存时间为 15个月 ,残留病灶≤ 2cm、化疗次数≥ 8、无肝实质转移的患者中位生存时间明显较相应的对照组长 (P <0 0 1) ;经多因素分析 ,年龄、病理类型、分化程度对预后无显著性影响。结论 彻底的缩瘤术、积极适宜的化疗是提高Ⅳ期上皮性卵巢癌患者生存期的必要手段。
Objective To explore the factors affecting the prognosis of stage Ⅳ epithelial ovarian cancer. Methods The clinical data of 31 cases of stage Ⅳ epithelial ovarian cancer treated in our hospital from January 1990 to May 1998 were retrospectively analyzed. The clinical data including the age, pathological type, degree of differentiation, metastatic sites, size of postoperative residual lesions, Number and life expectancy. Results The median overall survival time was 15 months. The median survival time of patients with residual lesions ≤ 2 cm and chemotherapy ≥ 8 without metastasis was significantly longer than that of corresponding controls (P <0.01). After multiple factors Analysis, age, pathological type, degree of differentiation had no significant effect on prognosis. Conclusions Thorough tumor shrinkage and aggressive chemotherapy are necessary measures to improve the survival of patients with stage IV epithelial ovarian cancer.