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应用遗传流行病学方法，对３５５个肺癌家族作配对调查，进行分离比、遗传度的估算和遗传易患性的相对风险估计。结果表明，肺癌分离比为０．０９～０．１２（９５％可信区间）；吸烟和非吸烟者遗传度分别为（４０．５８±４．０１）％和（２７．５８±４．７６）％；用ｌｏｇｉｓｔｉｃ回归模型调整吸烟（包／年）数，一二级亲属的相对风险分别为４．７３（３．９０～５．７４）和２．６１（２．１８～３．１３）；同时发现吸烟习惯和肺癌的遗传背景有交互作用。因此认为肺癌的遗传背景是肺癌多因素病因之一。
Using a genetic epidemiological approach, a paired survey of 355 lung cancer families was conducted to estimate segregation ratios, heritability, and relative risk estimates of genetic susceptibility. The results showed that the lung cancer isolation ratio was 0.09 to 0.12 (95% confidence interval); the heritability of smoking and non-smokers was (40.58±4.01)% and (27.58±4.76, respectively). )%; Using a logistic regression model to adjust the number of smoking (bags/year), the relative risks of the first- and second-degree relatives were 4.73 (3.90 to 5.74) and 2.61 (2.18 to 3.13), respectively. At the same time, it was found that smoking habits interact with the genetic background of lung cancer. Therefore, it is believed that the genetic background of lung cancer is one of the multifactorial causes of lung cancer.