局部应用噻吗洛尔治疗婴幼儿血管瘤(IH)被认为安全性更高,然而尚无充分的药代动力学数据支持,大部分研究对其系统吸收的效果没有报道。该文作者首次对采用0.5%噻吗洛尔凝胶治疗的IH患儿进行前瞻性研究,评估临床疗效,明确是否出现药物系统吸收。纳入研究的26例患儿通过了UCSD Topical application of timolol in the treatment of infantile hemangiomas (IH) is considered more safe, however, there is insufficient support for pharmacokinetic data and most studies have reported no effect on systemic absorption. For the first time, the authors prospectively studied children with IH treated with 0.5% timolol gel to assess the clinical efficacy and determine if systemic absorption occurred. Twenty-six children enrolled in the study passed UCSD