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本文报告原发性皮肤淀粉样变性715例,包括新发现的脂溢性皮炎样型71例和罕见的皮肤异色病样型(PCA)33例。指出早期病变的特征及其发生和发展规律。认为文献上所述各型仅代表寻常型的不同发展阶段。除蛋白质异常外,新发现血脂特别是甘油三酯增加。组织化学染色证明淀粉样蛋白沉积处有中性脂肪。红外光谱分析和中性脂肪薄层层析示皮损标本中甘油三酯和脂肪酸含量增加。提示脂
This article reports 715 primary amyloidosis cases, including 71 newly diagnosed cases of seborrheic dermatitis and 33 rare cases of PCA. Pointed out the characteristics of early lesions and its occurrence and development. It is considered that the various types mentioned in the literature represent only the ordinary stages of development. In addition to protein abnormalities, newly discovered increased blood lipids, especially triglycerides. Histochemical staining showed that there was neutral fat in the amyloid deposits. Infrared spectroscopy and neutracolysis revealed increased levels of triglycerides and fatty acids in lesions. Tip fat