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利用葡聚糖凝胶（DG）首次特异地减慢水杨酸钠（SS）从胰岛素直肠栓剂（INS）中的释放速度，而不影响胰岛素（IN）的释放，从而达到两者同步吸收的作用。试验证明，含200mg大交联度DG即DGG－10的INS与不含SG－10的INS相比能明显增加INS中IN在免直肠中的吸收量，致使兔血浆中IN最大浓度不变的情况下，持续时间明显延长，进而血溏浓度下降持续时间延长。INS中含400mgDGG-10反而使血浆中IN浓度和血糖浓度的变化程度小于不含DGG－10INS，分析可能是过量的DGG－10过度地减慢了SS从INS中的释放速度，以至于SS始终不能达到促进IN吸收的浓度的结果。
Dextran gels (DGs) are used for the first time to specifically slow the release of sodium salicylate (SS) from insulin rectal suppositories (INS) without affecting the release of insulin (IN), thereby achieving simultaneous absorption of both effect. Experiments show that with DG DG-200mg large degree of cross-linking of the INS and SG-10-containing INS can significantly increase INS IN in the rectum in the amount of absorption, resulting in rabbit plasma IN constant concentration Case, significantly longer duration, and thus reduce the duration of bloody 血 prolonged. In contrast, the inclusion of 400 mg of DGG-10 in INS resulted in less change in plasma IN concentration and blood glucose concentration than in absence of DGG-10INS, suggesting that excess DGG-10 may unduly slow the rate of release of SS from INS such that SS always The result of concentrations that promote IN absorption can not be achieved.