白血病的进展、疗效及预后判断临床上常通过诊断时的细胞数,细胞类型,细胞遗传学的改变等几方面进行综合评价。随着分子生物学的不断深入研究,近年来发现细胞端粒酶与肿瘤发生、发展密切相关。无限增殖是细胞癌变的重要生物学特征,端粒酶的发现揭开了白血病细胞无限增殖的面纱,为白血病的治疗寻找出新的靶点,对白血病的诊断、进展、疗效评价及预后判断有较高的临床价值。 Progress, efficacy and prognosis of leukemia in clinical diagnosis often through the number of cells, cell types, changes in cytogenetic and other aspects of a comprehensive evaluation. With the continuous study of molecular biology, in recent years, it has been found that telomerase is closely related to tumorigenesis and development. Infinite proliferation is an important biological feature of cancerous cells. The discovery of telomerase opens up the veil of unlimited proliferation of leukemia cells, and finds a new target for the treatment of leukemia. The diagnosis, progress, therapeutic evaluation and prognosis of leukemia are as follows: High clinical value.