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目的观察磷霉素治疗老年迁延型菌痢的疗效。方法将160例分为两组。治疗组84例,男48例,女36例,年龄:60~70岁48例,70~80岁20例,>80岁16例。对照组76例,男42例,女34例,年龄60~70岁45例,70~80岁19例,>80岁12例。治疗组:84例均以磷霉素4.0g/次,稀释于10%葡萄糖液250 mL内,静脉滴注,1d 2次,7d一疗程。对照组:76例给予头孢曲松,均以2.0g/次,稀释于生理盐水液100 mL内,静脉滴注,1d 2次,7d为一疗程。结果磷霉素组84例,显效82例(97.6%),有效2例(2.4%),总有效率100%;对照组76例中,三数率分别为43(56.6%),13(17.1%),56(73.7%),无效20例(26.3%),两组疗效相比,χ2=74.84,P<0.001,差异有统计学意义。且对照组中治疗无效病例再应用磷霉素治疗全部治愈。结论结果显示磷霉素静脉滴注治疗老年迁延型菌痢,疗效满意,有良好的安全性,值得在基层推广应用。
Objective To observe the efficacy of fosfomycin in the treatment of elderly extended-type bacillary dysentery. Methods 160 cases were divided into two groups. Treatment group of 84 patients, 48 males and 36 females, age: 48 years old 60 cases, 20 cases 70 to 80 years, 16 cases> 80 years. The control group of 76 patients, 42 males and 34 females, aged 60 to 70 years in 45 cases, 70 to 80 years in 19 cases,> 80 years in 12 cases. Treatment group: 84 cases were treated with fosfomycin 4.0g / time, diluted in 10% glucose solution 250 mL, intravenous infusion, 1d 2 times, 7d a course of treatment. In the control group, 76 patients were given ceftriaxone, 2.0g / time, diluted in 100 mL of saline, intravenous infusion, 1d 2 times, 7d for a course of treatment. Results In the fosfomycin group, 84 cases were markedly effective, 82 cases were markedly effective (97.6%), 2 cases were effective (2.4%), and the total effective rate was 100%. Among the 76 cases in the control group, the three numbers were 43 %), 56 (73.7%) and 20 ineffective (26.3%). There was significant difference between the two groups in curative effect χ2 = 74.84, P <0.001. And the control group of patients with invalid treatment and then applied fosfomycin treatment of all cured. Conclusion The results show that intravenous infusion of fosfomycin treatment of elderly extended-type bacillary dysentery, satisfactory results, good safety, it is worth promoting in the grass-roots applications.