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本文研究了重组人白细胞干扰素(IFN-αA和IFN-αD)及其5个杂交分子[IFN-αA/D(Bgl)、IFN-αA/D(Pvu)、IFN-αD/A(Bgl)、IFN-αD/A(Pvu)和IFN-αA/D/A]在3种不同细胞上对逆转录病毒、水泡性口炎病毒(VSV)和脑心肌炎病毒(EMCV)的抗病毒活性,目的是测定IFN在不同细胞内抗逆转录病毒和抗VSV的活性是否平行.实验用的猫F1F3细胞是1株慢性感染猫白血病病毒(FeLV)的纤维母细胞株;人RD-114细胞是能够持续产生RD-114逆转录病毒的细胞株;鼠NIH/MOL,C株是慢性感染鼠Moloney白血病病毒的NIH/3T3细胞.作者用观察病毒产
In this paper, the effects of recombinant human leukocyte interferon (IFN-αA and IFN-αD) and its five hybrid molecules [IFN-αA / D (Bgl) , Antiviral activity of IFN-αD / A (Pvu) and IFN-αA / D / A] on retrovirus, vesicular stomatitis virus (VSV) and encephalomyocarditis virus (EMCV) on 3 different cells, Is to determine whether the activity of IFN in different cells against anti-retroviral and anti-VSV parallel .Fat F1F3 experimental experimental cats is a chronic feline leukemia virus (FeLV) fibroblast strains; human RD-114 cells are able to last The mouse NIH / MOL strain C is NIH / 3T3 cells which are chronically infected with Moloney leukemia virus. The authors used the observation of virus production