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目的 通过对生精障碍患者外周血染色体核型的分析,探讨染色体核型异常与男性不育的关系.方法 常规制作外周血染色体G显带,对494例生精障碍患者进行染色体核型分析.结果 在494例生精障碍患者中,共检出染色体异常30例,发生率为6.07％ (30/494),其中无精症、严重少精症和少精症患者的发生率分别为11.86％ (21/177)、3.39％(6/177)、2.08％ (3/144).在异常染色体核型中,有1 3例(13/30,43.33％)发生染色体数目异常,1 7例(17/30,56.67％)发生染色体结构异常,其中14例(14/30,46.67％)是性染色体异常,16例(16/30,53.33％)是常染色体异常.在所有核型中,Klinefelter综合征的发生率最高,占异常核型的43.33％.结论 生精障碍功能越严重,染色体异常核型检出率越高.因此有必要对生精障碍的患者进行染色体核型分析,从而帮患者找出病因,明确诊断,为进行辅助生育的不育患者提供遗传咨询,避免将缺陷传给后代.“,”Objective:To analyze the karyotypes of spermaatogenesis impairment patients so as to investigate the correlation of male infertility with chromosome abnormalities.Methods:Chromosome Karyotypes analyses were performed in the 494 spermaatogenesis impairment patients on peripheral blood lymphocytes according to standard methods and analyzed by chromosome G banding.Results:Totally,there were 30 cases with chromosomal construction and quantity abnormalities were detected in 494 infertile men with spermatogenesis impairment,the rate of chromosomal abnormalities were 6.07 (30/494),and were 11.86％ (21/177) 、3.39％ (6/177) 、2.08％ (3/144) in azoospermia,severe oligozoospermia and oligozoospermia,respectively,including 13 (13/30,43.33％) cases with chromosomal quantity abnormalities,and 17 (17/30,56.67％) cases with chromosomal construction abnormalities.In these cases,14 cases (14/30,46.67％) of sex abnormal karyotype and 16例 (16/30,53.33％) of autosome abnormal karyotype. The klinefelter syndrome wsa the most common disease caused by abnormal karyotype and the ration was 43.33％ in all the abnormal karyotypes.Conclusion:Severe spermatogenesis failure usually means higher rate of chromosome abnormality,Karyotype analysis is important for the diagnosis and treatment of male infertility.