抗心律失常药治疗中经常并用制酸剂,以克服这些药物的胃肠道反应。体外试验表明:制酸剂能够不同程度地吸附某些抗心律失常药,并影响它们通过人造肠粘膜的扩散速率。本文报告给实验狗服用单剂量氢氧化铝和氧化镁,以考察其对治疗指数较窄的三个主要抗心律失常药物奎尼丁、普鲁卡因胺及心得安生物利用度的影响。 Anti-arrhythmic drugs often use antacids in the treatment of these drugs to overcome the gastrointestinal reaction. In vitro tests show that antacids can adsorb certain antiarrhythmic drugs to varying degrees and affect their diffusion rate through artificial intestinal mucosa. This article reports single-dose aluminum hydroxide and magnesium oxide in experimental dogs to investigate their effects on the availability of quinidine, procainamide and propranolol, the three major antiarrhythmic drugs with a narrow therapeutic index.