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目的：了解糖尿病对睾丸间质细胞（Ｌｅｙｄｉｇ细胞）功能和形态的影响。方法：用链脲佐菌素诱导制成糖尿病大鼠模型，２个月后处死大鼠，测定血清睾酮及睾丸组织ｈＣＧ结合位点，并用光镜和电镜作了睾丸形态学观察。结果：糖尿病大鼠的血清睾酮水平及睾丸组织的ｈＣＧ结合位点水平明显低于正常对照组（Ｐ＜０．０１）；糖尿病大鼠Ｌｅｙｄｉｇ细胞萎缩，内质网、线粒体等细胞器空泡样变。结论：糖尿病可使Ｌｅｙｄｉｇ细胞功能降低，结构变性。
Objective: To understand the effect of diabetes on the function and morphology of Leydig cells. Methods: Diabetic rats were induced by streptozotocin. After 2 months, the rats were sacrificed and the hCG binding sites of serum testosterone and testis were determined. Morphological changes of testis were observed by light microscope and electron microscope. Results: The levels of serum testosterone and hCG binding sites in diabetic rats were significantly lower than those in normal controls (P <0.01). The atrophy of Leydig cells and vacuolization of endoplasmic reticulum and mitochondria in diabetic rats were observed . Conclusion: Diabetes can reduce the function of Leydig cells and cause structural degeneration.