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利福定是我国首创的半合成抗结核新药,其耐药机理国内外尚未见报道。本文用同位素前体参入法研究表明,利福定迅速而高效地抑制敏感菌(大肠杆菌及金葡球菌)[~3H]UR参入而对耐药菌无抑制作用或仅有轻微抑制作用。[~3H]利福定参入大肠杆菌敏感菌的量明显
Rifadin is China’s first semi-synthetic antituberculosis drugs, the mechanism of its resistance has not been reported at home and abroad. In this paper, isotope precursor incorporation studies indicate that rifavin quickly and efficiently inhibit the sensitive bacteria (E. coli and Staphylococcus aureus) [~ 3H] UR incorporation of drug-resistant bacteria without inhibition or only a slight inhibitory effect. [~ 3H] rifamycin into E. coli sensitive bacteria significantly