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Phenols motifs are used as common versatile synthons in organic synthesis due to their wide availability and low cost.Thus, C-H functionalization of phenols is highly attractive to the community of synthetic chemistry. In the past decade, many methods have been developed via installing a protective group on the hydroxyl to allow for ortho/meta/para functionalization of phenols. One of the most effective methods for direct C-H functionalization is the carbene
Phenols motifs are used as common versatile synthons in organic synthesis due to their wide availability and low cost.Thus, CH functionalization of phenols is highly attractive to the community of synthetic chemistry. In the past decade, many methods have been developed via installing a protective group on the hydroxyl to allow for ortho / meta / para functionalization of phenols. One of the most effective methods for direct CH functionalization is the carbene