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[目的]探讨高危型HPV负荷量与宫颈病变及术后病毒持续感染的关系。[方法]对2008年1月至2012年11月体检发现的高危型HPV阳性且行宫颈LEEP术的749例患者临床资料及随访结果进行分析,观察高危型HPV负荷量与宫颈病变及术后病毒持续感染的关系。[结果]高危型HPV负荷量越大,宫颈病变级别越高。术后3个月高危型HPV阳性率约27.9%;术后6个月约8.3%;术后9个月约4.0%。宫颈LEEP术后3、6个月患者高危型HPV阳性表达率下降显著(术后3个月vs术前:χ2=844.38,P=0.0001;术后6个月vs术后3个月:χ2=97.35,P=0.0001);术后9个月高危型HPV阳性表达率较术后6个月下降,但无显著性差异。术前高危型HPV负荷量<100RLU/CO、100~1000RLU/CO及>1000RLU/CO三组术后6个月复查HPV阳性率分别为5.3%、9.4%及12.9%(P<0.05)。[结论]高危型HPV负荷量与宫颈病变严重程度及持续感染存在明显相关性,针对高负荷量者需严密诊治及随访。
[Objective] To investigate the relationship between high-risk HPV load and cervical lesions and postoperative virus infection. [Methods] The clinical data and follow-up results of 749 high-risk HPV-positive cervical LEEP patients from January 2008 to November 2012 were analyzed. The incidence of high-risk HPV infection and cervical lesions and post-surgical virus persisted Infected relationship. [Results] The higher the load of high-risk HPV, the higher the grade of cervical lesions. The positive rate of high-risk HPV was 27.9% at 3 months postoperatively, 8.3% at 6 months postoperatively and 4.0% at 9 months postoperatively. The positive rate of high-risk HPV in 3 and 6 months after cervical LEEP was significantly decreased (3 months after surgery vs 2 days before surgery: χ2 = 844.38, P = 0.0001; 6 months vs 3 months after surgery: χ2 = 97.35, P = 0.0001). The positive rate of high-risk HPV in 9 months after operation was lower than that in 6 months after operation, but there was no significant difference. The HPV positive rates of preoperative high risk HPV load <100 RLU / CO, 100 ~ 1000 RLU / CO and> 1000 RLU / CO were 5.3%, 9.4% and 12.9% respectively at 6 months after operation (P <0.05). [Conclusion] There is a significant correlation between the load of high-risk HPV and the severity of cervical lesions and persistent infection. Patients with high load should be closely diagnosed and followed up.