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为研究SAA和MDS骨髓Th细胞亚群的数量及比例改变情况。用FACS同期对照研究 16例正常对照组、 2 4例发病期SAA、 15例MDS骨髓Th细胞的改变。结果显示 ,正常对照组Th1、Th2细胞及Th1/Th2为 :0 33%、 0 34%、 1 0 0 ,发病期SAA为 :4 4 2 %、 0 4 0 %、 10 5 7,恢复期SAA为 :0 39%、 0 2 0 %、 0 92 % ,MDS为 :0 4 1%、 0 5 7%、 0 75。发病期SAA的Th1、Th2细胞均显著增高 (P <0 0 1、 0 0 5 ) ,Th1/Th2显著向Th1偏移 (P <0 0 1) ;恢复期SAA与正常对照基本相当 (P>0 0 5 )。与正常对照组比较 ,MDS组的Th1细胞未升高 (P >0 0 5 ) ,亦显著低于发病期SAA组 (P <0 0 1) ,虽然Th2细胞升高 ,但无统计学意义 (P >0 0 5 ) ,但Th1/Th2比值降低 (P <0 0 5 ) ,向Th2偏移。SAA的发病可能由于Th1细胞增多 ,Th2细胞代偿不足 ,Th1/Th2向Th1偏移 ;MDS骨髓Th1细胞改变不显著 ,Th2有增多的趋势 ,Th1/Th2向Th2偏移
To investigate the changes in the number and proportion of Th cell subsets in the bone marrow of SAA and MDS. 16 cases of normal control group, 24 cases of SAA during onset and 15 cases of MDS bone marrow Th cells were studied by FACS. The results showed that the normal control group Th1, Th2 cells and Th1 / Th2: 0 33%, 0 34%, 1 0 0, the incidence of SAA was: 442%, 0 4 0%, 107 57, convalescent SAA As follows: 0 39%, 0 2 0%, 0 92%, MDS 0 4 1%, 0 5 7%, 0 75. Th1 and Th2 cells were significantly increased in SAA during onset (P <0.01 or 0.55), Th1 / Th2 was significantly shifted to Th1 (P <0.01), and SAA in recovery phase was almost the same as that in normal control (P> 0 0 5). Compared with normal control group, Th1 cells in MDS group were not increased (P> 0.05), but also significantly lower than those in SAA group (P <0.01). Although Th2 cells were increased, there was no significant difference (P> P> 0.05), but the Th1 / Th2 ratio decreased (P <0 05) and shifted to Th2. The incidence of SAA may be due to an increase of Th1 cells, insufficient compensation of Th2 cells and a shift of Th1 / Th2 to Th1; not obvious change of Th1 cells in MDS bone marrow, increase of Th2, change of Th1 / Th2 to Th2