论文部分内容阅读
目的：测定泼尼松所致大鼠骨质疏松的骨密度和力学性能。方法：采用１６只３月龄雄性ＳＤ大鼠，体重３４５～３４７ｇ，随机分为对照组和实验组，后者喂醋酸泼尼松４．５ｍｇ／ｋｇ，２次／周。９０天后对两组动物股骨分别进行单光子骨密度测定和扭转试验。结果：实验组股骨近段、中段和远段的骨密度分别减少了１２．４％（Ｐ＜０．０５）、１３．９％（Ｐ＜０．０５）和１１．９％（Ｐ＜０．０５）；股骨干抗扭转各项指标均出现减少趋势。结论：长期使用ＧＣ，会导致骨矿含量减少，由于骨的构筑发生了改变，使其抵抗扭转的能力降低，从而易发生骨折
OBJECTIVE: To determine the bone density and mechanical properties of prednisone-induced osteoporosis in rats. Methods: Sixteen 3-month-old male Sprague-Dawley rats weighing 345-3 347 g were randomly divided into control group and experimental group. The latter was fed with 4.5 mg / kg prednisone acetate twice daily. After 90 days, the two groups of animal femurs were measured by single-photon bone density and torsion test. Results: The BMD of proximal, middle and distal femur decreased by 12.4% (P <0.05), 13.9% (P <0.05) and 11.9% (P <0) in experimental group .05); Anti-torsion femoral shaft indicators have shown a decreasing trend. CONCLUSIONS: Long-term use of GC results in a decrease in bone mineral content, which is susceptible to fracture due to changes in bone architecture that reduce its ability to resist twisting