1933年Wintrobe与Buell报告一例多发性骨髓瘤,其血清在低温时沉淀,加温后又溶解。1947年Lerner与Watson称此种蛋白为冷球蛋白。现知,冷球蛋白存在于多种疾病中,诸如骨髓瘤与巨球蛋白血症、慢淋及淋巴瘤、结节性多动脉炎、肝硬化、网细胞增生症、结节病、系统性红斑狼疮、类风湿关节炎、强直性脊椎炎、干燥综合征、溶血性贫血、亚急性 In 1933 Wintrobe and Buell reported a case of multiple myeloma, the sera precipitated at low temperatures, dissolved again after warming. In 1947 Lerner and Watson called this protein cryoglobulins. It is known that cryoglobulins are present in a variety of diseases, such as myeloma and macroglobulinemia, chronic lymph and lymphoma, polyarteritis nodosa, cirrhosis, neutrophilia, sarcoidosis, systemic Lupus, rheumatoid arthritis, ankylosing spondylitis, Sjogren’s syndrome, hemolytic anemia, subacute