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目的:评价尖吻蝮蛇凝血酶治疗消化性溃疡出血的有效性和安全性。方法:选取2014年4月~2015年4月我院消化科收治的消化性溃疡出血患者100例为研究对象,根据病情程度分为轻度、中度和重度,将入选患者随机分为观察组和对照组,每组各50例。对照组在抑酸、消炎和保护胃黏膜等常规治疗基础上采用垂体后叶素止血,观察组在上述常规治疗基础上采用尖吻蝮蛇凝血酶止血,比较观察两组不同病情程度患者的临床疗效和有既往心脑血栓病史患者再次发生血栓的情况。结果:观察组中度、重度患者的疗效明显优于对照组中、重度患者,且差异有统计学意义(P<0.05),观察组中有既往心脑血栓病史的患者无再次发生血栓。结论:尖吻蝮蛇凝血酶治疗消化性溃疡出血具有较好的疗效和安全性。
Objective: To evaluate the efficacy and safety of Agkistrodon acutus venom thrombin in the treatment of peptic ulcer bleeding. Methods: A total of 100 patients with peptic ulcer bleeding admitted to our department from April 2014 to April 2015 were selected as study subjects. The patients were divided into mild, moderate and severe according to their severity. The patients were randomly divided into observation group And control group, 50 cases in each group. The control group in the acid suppression, anti-inflammatory and gastric mucosa and other conventional treatment based on the use of pituitrin hemostasis, the observation group in the conventional treatment based on the use of Agkistrodon antirrhinorhexis, compared two groups of patients with different degrees of clinical Efficacy and history of previous thrombosis in patients with thrombosis again. Results: The curative effect of moderate and severe patients in the observation group was significantly better than that of the moderate and severe patients in the control group (P <0.05). No thrombosis occurred in the patients with previous history of cardiovascular and cerebrovascular thrombosis in the observation group. Conclusion: The treatment of peptic ulcer with viper snake thrombin has good curative effect and safety.