对进行性肌营养不良症发病机制的研究已经进行了多年,曾经提出神经源学说、血管源学说和肌源学说,神经源、血管源学说缺乏足够的根据而放弃,而肌源学说随着分子生物学的进步而逐渐深入。近年来证明了肌膜存在超微结构异常,膜脂成分异常,肌浆网膜钙离子摄取降低,最有兴趣的发现是肌膜 ATP 酶改变。肌膜 ATP 酶包括Na~+K~+ATP 酶、Mg~(++)ATP 酶和 Ca~(++)ATP酶,其中 Na~+K~+ATP 酶与离子转运、兴奋 The study of the pathogenesis of progressive muscular dystrophy has been going on for many years. Neurological theory, vasogenic theory, myogenic theory, neurogenic and vasculogenic theory have been proposed for a long time. However, Advances in biology and gradually in-depth. In recent years, it has been proved that there are ultrastructural abnormalities in the muscle membrane, abnormal membrane lipid composition, and decreased sarcoplasmic reticulum calcium uptake. The most interesting finding is that the muscle ATPase changes. Myofascial ATPases include Na ~ + K ~ + ATPase, Mg ~ (++) ATPase and Ca ~ (++) ATPase, of which Na ~ + K ~ + ATPase and ion transport, excitement