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红细胞破坏的机理十分复杂,至今尚未彻底明了。免疫破坏无疑是其重要的机理之一。衰老和异常的红细胞在体内能经体液免疫和体液与细胞免疫结合的机理破坏。体液免疫破坏是红细胞在体内经抗体介导,通过激活补体经典途径被破坏而导致血管内溶血。红细胞免疫破坏的最常见机理还是体液与细胞免疫相结合。当红细胞被IgG和/或补体C_3b致敏后,能和某些具有相应受体的效应细胞(如巨噬细胞、单核细胞、某些淋巴细胞和粒细胞)相互作用,引起红细胞在血管外破坏。在这些效应细胞中,似乎以巨噬细胞的作用最重要。包被
The mechanism of erythrocyte destruction is very complicated, so far not completely understood. Immunity is undoubtedly one of the important mechanisms. Senescent and abnormal erythrocytes are destroyed in the body by the mechanisms of humoral immunity and the combination of humoral and cellular immunity. Humoral immune destruction of red blood cells in the body by antibody-mediated, by activating the complement of the classical pathway is destroyed and lead to intravascular hemolysis. The most common mechanism of erythrocyte immune destruction is the combination of humoral and cellular immunity. When erythrocytes are sensitized with IgG and / or complement C_3b, they interact with certain effector cells (such as macrophages, monocytes, certain lymphocytes and granulocytes) that have the corresponding receptors, causing the erythrocytes to become extravascular damage. Among these effector cells, it seems that the role of macrophages is the most important. Coated